Manon De Pauw's work has been shown at the Musée d'art contemporain de Montréal, Théâtre La Chapelle, Centro Nacional de las artes in Mexico City, the Festival des films sur l'art and the Art Gallery of Nova Scotia, among others. In 2009, the Galerie de l'UQAM and curator Louise Déry presented the exhibition Manon De Pauw - Intrigues, which toured to the Musée Régional de Rimouski (2011) and the Centre Culturel Canadien in Paris (2012). In 2010, she curated the exhibition Actes de présence at the Musée d'art contemporain de Montréal as part of her series Point de vue sur la collection. In 2011, she was the Quebec finalist for the Sobey Arts Award, and in 2012, the visual arts winner of the Canada Council for the Arts Victor Martyn Lynch-Staunton Award.
In addition to her individual projects, she has several collaborations to her credit, notably with choreographer Danièle Desnoyers and musicians and composers André Pappathomas, Joane Hétu and Philippe B. In 2014, she presented the interdisciplinary performance La matière ordinaire at Usine C as part of the Festival Temps d'Images. In spring 2017, she presented Cocons somatiques at Agora de la danse in collaboration with dancer and choreographer Pierre-Marc Ouellette. The same year, she participated as visual designer and performer in Un si gentil garçon, a Théâtre Complice creation at Usine C. Manon De Pauw lives and works in Montreal. She is represented by Galerie Divison and teaches at UQÀM's School of Visual and Media Arts.